Forecasting for the Pharmaceutical Industry is a definitive guide for forecasters as well as the multitude of decision makers and executives who rely on forecasts in their decision making. In virtually every decision, a pharmaceutical executive considers some type of forecast. This process of predicting the future is crucial to many aspects of the company - from next month's production schedule, to market estimates for drugs in the next decade. The pharmaceutical forecaster needs to strike a delicate balance between over-engineering the forecast - including rafts of data and complex 'black box' equations that few stakeholders understand and even fewer buy into - and an overly simplistic approach that relies too heavily on anecdotal information and opinion. Arthur G. Cook's highly pragmatic guide explains the basis of a successful balanced forecast for products in development as well as currently marketed products. The author explores the pharmaceutical forecasting process; the varied tools and methods for new product and in-market forecasting; how they can be used to communicate market dynamics to the various stakeholders; and the strengths and weaknesses of different forecast approaches. The text is liberally illustrated with tables, diagrams and examples. The final extended case study provides the reader with an opportunity to test out their knowledge. The second edition has been updated throughout and includes a brand new chapter focusing on specialized topics such as forecasting for orphan drugs and biosimilars.

In virtually every decision, a pharmaceutical executive considers some type of forecast. This process of predicting the future is crucial to many aspects of the company - from next month's production schedule, to market estimates for drugs in the next decade. The pharmaceutical forecaster needs to strike a delicate balance between over-engineering the forecast - including rafts of data and complex 'black box' equations that few stakeholders understand and even fewer buy into - and an overly simplistic approach that relies too heavily on anecdotal information and opinion. Art Cook's highly pragmatic guide explains the basis of a successful balanced forecast for products in development as well as currently marketed products. The author explores the pharmaceutical forecasting process; the varied tools and methods for new product and in-market forecasting; how they can be used to communicate market dynamics to the various stakeholders; and the strengths and weaknesses of different forecast approaches. The text is liberally illustrated with tables, diagrams and examples. The final extended case study provides the reader with an opportunity to test out their knowledge. Forecasting for the Pharmaceutical Industry is a definitive guide for forecasters as well as the multitude of decision makers and executives who rely on forecasts in their decision making.

It is important that stakeholders are aware of practices supported as effective for students with learning and behavioral disabilities in order to provide instruction that results in improved learner outcomes. Perhaps equally important, stakeholders should also know which practices have been shown by research to be ineffective (e.g., have no, small, or inconsistent effects on learner outcomes). Special education has a long history of using practices that, though appealing in some ways, have little or no positive impact on learner outcomes. In order to bridge the gap between research and practice, educators must be aware of which practices work (and prioritize their use) and which do not (and avoid their use). In this volume, each chapter describes two practices one supported as effective by research and one shown by research to be ineffective in critical areas of education for students with learning and behavioral disabilities. Chapter authors will provide readers guidance in how to do this for each effective practices and provide concrete reasons to not do this for each ineffective practice.

How do students with learning disabilities or emotional and behavioral disorders fare in adulthood? Are their rates of employment, graduation from post-secondary schools, living independently similar to their non-disabled peers? What can schools and communities do to teach and support youth and young adults with learning disabilities or emotional and behavioral disorders? This Transition of Youth and Young Adult volume presents eminent scholars discussing critical and timely topics related to the transition of youth and young adults with learning disabilities and emotional and behavioral disorders and provides a comprehensive selection of chapters that address variables, issues, practices, and outcomes related to the broad topic of transition.

Drawing on a wide range of Chinese and western sources, this book offers in-depth analysis of the complete range of environmental problems facing China today, from the historical, political, economic and cultural root causes, through the successful and unsuccessful efforts which have been made to find solutions, to possible future scenarios and strategies.

Published in 1998, this book examines the challenges and opportunities for international business and trade in the Asia-Pacific region, highlighting the dynamic and complexities of the region.

Drawing on a wide range of Chinese and western sources, this book offers in-depth analysis of the complete range of environmental problems facing China today, from the historical, political, economic and cultural root causes, through the successful and unsuccessful efforts which have been made to find solutions, to possible future scenarios and strategies.

eBook available with sample pages: 020322065X

Published in 1998, this book examines the challenges and opportunities for international business and trade in the Asia-Pacific region, highlighting the dynamic and complexities of the region.

Intensive, individualized interventions are certainly the hallmark promise of special education. In a multi-tiered system of supports (MTSS), tier 3 interventions are the most intensive and require individualized delivery to address the learning and behavioral needs of students who are most often identified for special education services. MTSS, such as Responsiveness to Intervention (RTI) and Positive Behavioral Interventions and Supports (PBIS), are comprised of universal assessment, progress monitoring, and databased decision-making as intervention is implemented with increasing intensity and individualization based on the needs of the learner. The chapters in this volume cover a broad range of topics that address issues surrounding the identification of students who need the most intensive intervention, intensive intervention features and delivery considerations, behavioral interventions, academic interventions, and preservice teacher preparation. The authors of the chapters are recognized as international experts on these topics and provide specific recommendations that are based on research evidence as well as discuss considerations for future enhancement of multi-tiered systems of supports and intensive interventions. This is a contemporary resource for teachers, administrators, and teacher-educators who are charged with delivering special education and/or supporting those who do.

In virtually every decision, a pharmaceutical executive considers some type of forecast. This process of predicting the future is crucial to many aspects of the company - from next month's production schedule, to market estimates for drugs in the next decade. The pharmaceutical forecaster needs to strike a delicate balance between over-engineering the forecast - including rafts of data and complex 'black box' equations that few stakeholders understand and even fewer buy into - and an overly simplistic approach that relies too heavily on anecdotal information and opinion. Art Cook's highly pragmatic guide explains the basis of a successful balanced forecast for products in development as well as currently marketed products. The author explores the pharmaceutical forecasting process; the varied tools and methods for new product and in-market forecasting; how they can be used to communicate market dynamics to the various stakeholders; and the strengths and weaknesses of different forecast approaches. The text is liberally illustrated with tables, diagrams and examples. The final extended case study provides the reader with an opportunity to test out their knowledge. Forecasting for the Pharmaceutical Industry is a definitive guide for forecasters as well as the multitude of decision makers and executives who rely on forecasts in their decision making.

Responding to the need for educational stakeholders to be equipped to plan for constantly evolving developments in policy and practice for learners with learning and behavioral disabilities, this edited collection collates contributions from authors who predict what the next big things in the field will be, and offer recommendations on how to prepare for the future they envision. The chapters cover a broad range of topics that include developments related to students' legal rights and services, how research is utilized by practitioners, using practice-based evidence to promote the use of evidence-base practices, open science, neuroscience and special education, professional development for teachers, adaptive tier-2 interventions, the field of emotional and behavioral disorders, reading and students with autism spectrum disorder, and innovations in early writing. Chronicling, too, the concerns and cautions that the authors have about what they see as the next big thing, this collection is a compelling resource for anyone looking to the future of the field, and thinking about how they can be at the front of developments in order to navigate change in a way that generates positive effects.

The challenges associated with the education and treatment of children and youth with emotional and behavioral disorders (EBD) have proven to be both persistent and exceedingly complex. Thus, our best hope for improving outcomes for students with or at risk for EBD lies not in miracle cures or the eradication of all disorders, but in the incremental progress that furthers our understanding of the nature of EBD, enabling us to systematically refine interventions. Toward these goals, this volume focuses on emerging research and issues related to students identified with or at risk of EBD. Chapters within the volume include reports of original research, and summaries of new and emerging research issues. Specific topics include: bullying; technology-based self-monitoring; issues around the direct observation of both student and teacher behavior; the characteristics of youth served in residential or other alternative settings because of their EBD; and the application of function-based logic to social skills intervention. Two additional chapters examine issues around identifying evidence-based practice in EBD, including guidance for practitioners who may be overwhelmed by the challenges of teaching students with EBD, as well as the vast array of resources they must sift through to locate credible and reliable information on effective interventions.

This volume explores serious challenging behavior in schools, with an emphasis on promising and research-based approaches to dealing with such behavior. Topics include what we know about (a) the nature and extent of the problem (e.g., rates of aggression, violence, and noncompliance in schools); (b) addressing extreme forms of noncompliance; (c) dealing with serious disruptive behavior; (d) violence prevention programs; (e) schoolwide response to aggression and violence; (f) issues of covert antisocial behavior (e.g., vandalism, truancy, theft); (g) functional behavioral assessment and function-based interventions; (h) legal and policy considerations in disciplining students with disabilities; and (i) promising and needed avenues for further research.

The focus of this volume is to identify and review issues and outcomes associated with behavioral concerns of students with learning and behavioral disabilities. Students must navigate a number of environmental conditions, task demands, and social interactions with peers and adults throughout the school day. To be successful, they must employ a variety of learning and self-regulatory strategies, as well as meet teachers' expectations in the classroom. Students with learning and behavioral disabilities are more likely to fail in navigating the school day than nondisabled peers. Their failure is often associated with difficulties in some aspect of behavior. In this volume, internationally prominent scholars address contemporary topics such as grade retention, bullying and Harassment, response-to-intervention and universal systems in relation to how students with learning and behavioral disabilities are affected by them. Additionally, the scholars describe and discuss future directions for treatments such as social skills instruction, cognitive-behavioral prevention, social emotional learning programs, and self-monitoring. The volume is intended to be of interest to clinicians, teachers, researchers, graduate students, and others who work with students with learning and behavioral disabilities.

Environmental Tracers in Subsurface Hydrology synthesizes the research of specialists into a comprehensive review of the application of environmental tracers to the study of soil water and groundwater flow. The book includes chapters which cover ionic tracers, noble gases, chlorofluorocarbons, tritium, chlorine-36, oxygen-18, deuterium, and isotopes of carbon, strontium, sulphur and nitrogen. Applications of the tracers include the estimation of vertical and horizontal groundwater velocities, groundwater recharge rates, inter-aquifer leakage and mixing processes, chemical processes and palaeohydrology. Practicing hydrologists, soil physicists and hydrology professors and students will find the book to be a valuable support in their work.

Environmental Tracers in Subsurface Hydrology synthesizes the research of specialists into a comprehensive review of the application of environmental tracers to the study of soil water and groundwater flow. The book includes chapters which cover ionic tracers, noble gases, chlorofluorocarbons, tritium, chlorine-36, oxygen-18, deuterium, and isotopes of carbon, strontium, sulphur and nitrogen. Applications of the tracers include the estimation of vertical and horizontal groundwater velocities, groundwater recharge rates, inter-aquifer leakage and mixing processes, chemical processes and palaeohydrology. Practicing hydrologists, soil physicists and hydrology professors and students will find the book to be a valuable support in their work.

This volume focuses on evidence-based practices (EBPs) , supported, sound research studies documenting their effectiveness with a target population. As such, EBPs have significant potential to improve the outcomes of learners with learning and behavioral disorders. However, a number of obstacles exist in identifying, conceptualizing, adopting, and maintaining EBPs that have prevented educators from realizing their potential benefits. The chapters in this volume address many of these issues, with the goal of improving stakeholders? Ability to identify and implement EBPs. Chapters discuss the following topics: appraising systematic evidence-based reviews, using single-subject research to identify EBPs, legal issues, implementation fidelity and EBPs, guidelines for implementing EBPs, obstacles to implementing EBPs, teacher preparation and EBPs, EBPs for learners with learning disabilities, EBPs for learners with behavioral disabilities, EBPs for learners with autism spectrum disorders, EBPs in early childhood special education, EBPs in special education in Australia.

An idea-packed catalog of projects, activities, and science fun sure to inspire future "Edisons" … The Thomas Edison Book of Easy and Incredible Experiments The Thomas Alva Edison Foundation Thomas Edison patented 1,093 inventions — and more chemistry experiments than any other scientist ever! This book reflects the fascination that he found in experimentation and presents the best, most popular experiments and projects sponsored by the prestigious Edison Foundation. Here, in one convenient volume, you will find a range of activities from the very simple (for primary or middle grades or individual young scientists at home) to the intriguingly complex (for older students, groups, or an entire class). These experiments require no science background. They utilize inexpensive, easy-to-obtain materials. Most of all, the projects are fun to build, safe and useful, and each provides a good demonstration of important scientific principles in real-life action! Most youngsters and teens can work on the experiments with little supervision, and there are ample ideas for science fairs and "extra credit" projects. Over 100 illustrations are included, plus photos of the legendary inventor himself. Experiments in this book encompass magnetism, electricity, electrochemistry, chemistry, physics, energy, and environmental studies — topics for varied interests in grades 4 through 11. Throughout, emphasis is on the essence of scientific "tinkering," experimenting for the pure fun of it … activities that lead to satisfying hobbies, new ideas, and learning. Edison himself would surely enjoy this book — so imagine that you are visiting his laboratory, and let this be your introduction to a world of discovery. …

Presents the normal kinematic and dynamic equations for robots, including mobile robots, with coordinate transformations and various control strategies This fully updated edition examines the use of mobile robots for sensing objects of interest, and focus primarily on control, navigation, and remote sensing. It also includes an entirely new section on modeling and control of autonomous underwater vehicles (AUVs), which exhibits unique complex three-dimensional dynamics. Mobile Robots: Navigation, Control and Sensing, Surface Robots and AUVs, Second Edition starts with a chapter on kinematic models for mobile robots. It then offers a detailed chapter on robot control, examining several different configurations of mobile robots. Following sections look at robot attitude and navigation. The application of Kalman Filtering is covered. Readers are also provided with a section on remote sensing and sensors. Other chapters discuss: target tracking, including multiple targets with multiple sensors; obstacle mapping and its application to robot navigation; operating a robotic manipulator; and remote sensing via UAVs. The last two sections deal with the dynamics modeling of AUVs and control of AUVs. In addition, this text: Includes two new chapters dealing with control of underwater vehicles Covers control schemes including linearization and use of linear control design methods, Lyapunov stability theory, and more Addresses the problem of ground registration of detected objects of interest given their pixel coordinates in the sensor frame Analyzes geo-registration errors as a function of sensor precision and sensor pointing uncertainty Mobile Robots: Navigation, Control and Sensing, Surface Robots and AUVs is intended for use as a textbook for a graduate course of the same title and can also serve as a reference book for practicing engineers working in related areas.

PET/CT in Clinical Practice provides guidelines for appropriate use of PET/CT in lung, lymphoma, esophageal, colorectal, head/neck and melanoma, with reference also made to tumors of the male and female reproductive system. Concise, relevant and illustrated with many interesting PET/CT images, each chapter contains a summary of the appropriate staging system. The range of normal PET/CT appearances is outlined in chapter 9. The book focuses on FDG-PET/CT throughout, but chapter 10 makes reference to the future application of other positron emitters and gives a beginners guide to the physics of PET/CT.

Everyone from medical student to consultant oncologist will be touched by this modality and all will need to understand its strengths and weaknesses. The book is essential reading for all consultants and medical students in radiology, nuclear medicine and oncology.

The Broadway sensation Hamilton has sparked renewed interest in the historical figures of Alexander Hamilton and Aaron Burr. This closely annotated thread of documents provides a riveting account of the lead-up to and aftermath of their disastrous duel. From the summer of 1804, we have the fiery correspondence between Hamilton and Burr, notes and accounts from their seconds-in-command, and other documents that provide an immediate sense of the personalities and times. The introduction and conclusion provide a concise and informative perspective on the parallel lives of Hamilton and Burr and of the duel's lasting impacts on American history. This is the perfect summary of the events that inspired the hit musical-a great resource for teachers and students and the perfect gift for history buffs.